The first paper from the Rich Lab is now published in PLoS Computational Biology. This work was spearheaded by one of the lab’s first undergraduate research assistants, Sibi Pandian, who is now pursuing his Master’s degree at John Hopkins University.
The manuscript describes the first computational model of dynamic, time-varying cholinergic modulation of the muscarinic m-current and its effects on the synchronization properties of simplified in silico cortical microcircuits. This lays the foundation for the lab’s ongoing explorations into this topic as it relates to vagus nerve stimulation in post-stroke motor rehabilitation.